Conditions Affecting Neurocognitive Development and Learning in Early Childhood

Publications & Presentations

For information on any presentations, posters, or other public CANDLE displays, please contact the document's first author.

1. Adkins, R. M., Klauser, C. K., Magann, E. F., Krushkal, J., Boyd, T. K., Fain, J. N., & Morrison, J.C. (2007). Site -2548 of the leptin gene is associated with gender-specific trends in newborn size and cord leptin levels. International Journal of Pediatric Obesity, 2(3), 130-137. PMID: 17852540

2. Adkins, R. M., Krushkal, J., Klauser, C. K., Magann, E. F., Morrison, J.C., & Somes, G. (2008). Association between small for gestational age and paternally inherited 5’ insulin haplotypes. International Journal of Obesity, 32(2), 372-380. Epub 2007. PMID: 17700581

3. Adkins, R. M., Somes, G., Morrison, J. C., Hill, J. B., Watson, E. M., Magann, E. F., & Krushkal, J. (2010). Association of birth weight with polymorphisms in the IGF2, H19, and IGF2R genes. Pediatric Research, 2010 68(5), 429-434. PMID: 20639793

4. Adkins, R. M., Krushkal, J., Magann, E. F., Klauser, C. K., Morrison, J. C., Ramsey, R., & Somes, G. (2010). Association of maternally inherited GNAS alleles with African-American male birth weight. International Journal of Pediatric Obesity, 5(2), 177-184. PMID: 19593725

5. Adkins RM, Krushkal J, Tylavsky FA, Thomas F. (2011). Racial differences in gene-specific DNA methylation levels are present at birth. Birth Defects Research A Clinical and Molecular Teratology. 91(8): 728-36. PMID: 21308978

6. Adkins RM, Thomas F, Tylavsky FA, Krushkal J. (2011). Parental ages and levels of DNA methylation in the newborn are correlated. BMC Med Genet. 12:47. PMID: 21453505

7. Schroeder JW, Conneely KN, CUbells JC, Kilaru V, Newport DJ, Knight BT, Stowe ZN, Brennan PA, Kruskal J, Tylavsky FA, Taylor RN, Adkins RM, Smith AK. (2011). Neonatal DNA methylation patterns associate with gestational age. Epigenetics. 1(6): 1498-504. PMID: 22139580

8. Adkins RM, Tylavsky FA, Krushkal J.(2012) Newborn umbilical cord blood DNA methylation and gene expression levels exhibit limited association with birth weight. Chem Biodivers. 9(5):888-99,. PMID: 22589090

9. Völgyi E, Carroll KN, Hare ME, Ringwald-Smith K, Piyathilake C, Yoo W, Tylavsky FA. (2013). Dietary Patterns in Pregnancy and Effects on Nutrient Intake in the Mid-South: The Conditions Affecting Neurocognitive Development and Learning in Early Childhood (CANDLE) Study. Nutrients. 5(5):1511-30. PMID: 23645026

10. Gardner, LM, Laura Murphy L, Campbell JM, Tylavsky F, Palmer FB, Graff JC. (2013). Screening accuracy for risk of autism spectrum disorder using the Brief Infant-Toddler Social and Emotional Assessment. Research in Autism Spectrum Disorders. 7(5):591-600.

11. Palmer FB, Anand KJ, Graff JC, Murphy LE, Qu Y, Völgyi E, Rovnaghi CR, Moore A, Tran QT, Tylavsky FA. (2013)  Early adversity, socioemotional development, and stress in urban 1-year-old children. J Pediatr. Dec;163(6):1733-1739.e1. doi: 10.1016/j.jpeds.2013.08.030. Epub 2013 Sep 24.PMID: 24070827

12. Smith AK, Kilaru V, Kocak M, Almli LM, Mercer KB, Ressler KJ, Tylavsky FA, Conneely KN. (2014). BMC Genomics. Methylation quantitative trait loci (meQTLs) are consistently detected across ancestry, developmental stage, and tissue type. Feb 21;15(1):145.

13. Krushkal J, Murphy LE, Palmer FB, Graff JC, Sutter TR, Mozhui K, Hovinga CA, Thomas F, Park V, Tylavsky FA, Adkins RM (2014). Epigenetic Analysis of Neurocognitive Development at 1 year of Age in a Community-Based Pregnancy Cohort. Behav Genet. Mar;44(2):113-25.

14. Rabito FA, Kocak M, Werthmann DW, Tylavsky FA, Palmer CD, Parsons PJ. (2014). Changes in low levels of lead over the course of pregnancy and the association with birth outcomes. Reprod Toxicol. Dec;50:138-44.

15. Colón-Ramos U, Racette SB, Ganiban J, Nguyen TG, Kocak M, Carroll KN, Völgyi E, Tylavsky FA.  (2015).  Association between dietary patterns during pregnancy and birth size measures in a diverse population in Southern US. Nutrients, 7: 1318-1332.

16. Mozhui K, Smith AK, Tylavsky FA (2015) Ancestry Dependent DNA methylation and influence of maternal nutrition. PLOS One, 1-17.

17. Tylavsky, F. A., Kocak, M., Murphy, L. E., Graff, J. C., Palmer, F. B., Volgyi, E., Diaz-Thomas, A. M., & Ferry, R. J. (2015). Gestational vitamin 25(OH)D status as a risk factor for receptive language development: A 24-month, longitudinal, observational study. Nutrients, 7: 9918 – 9930.

18. Volgyi, E., Rezaie, R., Hare, M. E., Tylavsky, F. A., & Papanicolaou, A. C. (2015). Physical activity, body composition and resting cortical activity in preschool children: Preliminary findings from the CANDLE study.  International Journal of School and Cognitive Psychology, 2: 124.

19. Sontag-Padilla LM, Burns RM, Shih R, Griffin BA, Martin LT, Chandra A, Tylavsky FA. The Urban Child Institute CANDLE Study Methodological overview and baseline sample description. Available from www.rand.org/t/rr1336

20. Ollberding NJ, Völgyi E, Macaluso M, Kumar R, Morrow C, Tylavsky FA, Piyathilake CJ.Urinary Microbiota Associated with Preterm Birth: Results from the Conditions Affecting Neurocognitive Development and Learning in Early Childhood (CANDLE) Study. PLoS One. 2016 Sep 9;11(9):e0162302. doi: 10.1371/journal.pone.0162302. eCollection 2016.

21. Arons A, Bolbocean C, Bush NR, Tylavsky FA, LeWinn KZ. Participation in the special supplemental nutrition program for women, infants, and children is not associated with early childhood socioemotional development: Results from a longitudinal cohort study. Prev Med Rep. 2016 Sep 7;4:507-11. doi: 10.1016/j.pmedr.2016.09.004. eCollection 2016 Dec.

22. Knight AK, Craig JM, Theda C, Bækvad-Hansen M, Bybjerg-Grauholm J, Hansen CS, Hollegaard MV, Hougaard DM, Mortensen PB, Weinsheimer SM, Werge TM, Brennan PA, Cubells JF, Newport DJ, Stowe ZN, Cheong JL, Dalach P, Doyle LW, Loke YJ, Baccarelli AA, Just AC, Wright RO, Téllez-Rojo MM, Svensson K, Trevisi L, Kennedy EM, Binder EB, Iurato S, Czamara D, Räikkönen K, Lahti JM, Pesonen AK, Kajantie E, Villa PM, Laivuori H, Hämäläinen E, Park HJ, Bailey LB, Parets SE, Kilaru V, Menon R, Horvath S, Bush NR, LeWinn KZ, Tylavsky FA, Conneely KN, Smith AK. An epigenetic clock for gestational age at birth based on blood methylation data. Genome Biol. 2016 Oct 7;17(1):206.

23. Graff JC, Bush AJ, Palmer FB, Murphy LE, Whitaker TM, Tylavsky FA. Maternal and Child Characteristics Associated With Mother-Child Interaction in One-Year-Olds. Res Nurs Health. 2017 Aug;40(4):323-340. doi: 10.1002/nur.21798. Epub 2017 Apr 18.

24. Thornburgh CL, Narayana S, Rezaie R, Bydlinski BN, Tylavsky FA, Papanicolaou AC, Choudhri AF, Völgyi E. Concordance of the Resting State Networks in Typically Developing, 6-to 7-Year-Old Children and Healthy Adults. Front Hum Neurosci. 2017 Apr 25;11:199. doi: 10.3389/fnhum.2017.00199. eCollection 2017.

25. Amoah DK, Nolan V, Relyea G, Gurney JG, Yu X, Tylavsky FA, Mzayek F. Factors associated with residential mobility during pregnancy. Women Health. 2017 Sep 18:1-12. doi: 10.1080/03630242.2017.1372843. [Epub ahead of print]

26. Kaplan EK, Collins CA, Tylavsky FA Cyclical unemployment and infant health.. Econ Hum Biol. 2017 Nov;27(Pt A):281-288. doi: 10.1016/j.ehb.2017.08.001. Epub 2017 Aug 2

27. Vereen S, Kocak M, Potukuchi PK, Hartman TJ, Tylavsky F, Carroll KN. The association of maternal prenatal vitamin D levels and child current wheeze. Ann Allergy Asthma Immunol. 2018 Jan;120(1):98-99. doi: 10.1016/j.anai.2017.10.005. Epub 2017 Nov 20.

28. Roy A, Kocak M, Hartman TJ, Vereen S, Adgent M, Piyathilake C, Tylavsky FA, Carroll KN. Association of prenatal folate status with early childhood wheeze and atopic dermatitis. Pediatr Allergy Immunol. 2018 Mar;29(2):144-150. doi: 10.1111/pai.12834. Epub 2017 Dec 19.

29. Nguyen AKD, Murphy LE, Kocak M, Tylavsky FA, Pagani LS. Prospective Associations Between Infant Sleep at 12 Months and Autism Spectrum Disorder Screening Scores at 24 Months in a Community-Based Birth Cohort. J Clin Psychiatry. 2018 Jan/Feb;79(1). pii: 16m11127. doi: 10.4088/JCP.16m11127.

30. Vereen S, Gebretsadik T, Johnson N, Hartman TJ, Veeranki SP, Piyathilake C, Mitchel EF, Kocak M, Cooper WO, Dupont WD, Tylavsky F, Carroll KN. Association Between Maternal 2nd Trimester Plasma Folate Levels and Infant Bronchiolitis. Matern Child Health J. 2018 Jul 19. doi: 10.1007/s10995-018-2610-2. [Epub ahead of print] PMID:30027465

31. Palmer FB, Graff JC, Jones TL, Murphy LE, Keisling BL, Whitaker TM, Wang L, Tylavsky F,. Socio-demographic, maternal, and child indicators of socioemotional problems in 2-year-old children: A cohort study. Medicine (Baltimore). 2018 Jul;97(28):e11468.  PMID:29995806

32. Slopen N, Roberts AL, LeWinn KZ, Bush NR, Rovnaghi CR, Tylavsky F, Anand KJS. Maternal experiences of trauma and hair cortisol in early childhood in a prospective cohort. Psychoneuroendocrinology. 2018 Aug 22;98: 168-176. PMID:30170311

33. Reidy KJ, Hjorten RC, Simpson CL, Rosenberg AZ, Rosenblum SD, Kovesdy CP, Tylavsky F, Myrie J, Ruiz BL, Haque S, Mozhui K, Nelson GW, David VA, Yang X, Suzuki M, Jacob J, Reznik SE, Kaskel FJ, Kopp JB, Winkler CA, Davis RL. Fetal-not Maternal-APOL1 Genotype Associated with Risk for Preeclampsia in Those with African Ancestry. Am J Hum Genet. 2018 Aug 21. PMID: 30173819 https://doi.org/10.1016/j.ajhg.2018.08.002

34. Anand KJS, Rigdon J, Rovnaghi CR, et al. Measuring socioeconomic adversity in early life. Acta Paediatr. 2019.

35. Hu Z, Tylavsky FA, Han JC, et al. Maternal metabolic factors during pregnancy predict early childhood growth trajectories and obesity risk: the CANDLE Study. International journal of obesity. 2019.

36. Shin EK, LeWinn K, Bush N, Tylavsky FA, Davis RL, Shaban-Nejad A. Association of Maternal Social Relationships With Cognitive Development in Early Childhood. JAMA Netw Open. 2019;2(1):e186963.

37. Adams SN, Adgent MA, Gebretsadik T, et al. Prenatal vitamin D levels and child wheeze and asthma. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstet. 2019:1-9.

38. Hamad R, Batra A, Karasek D, LeWinn KZ, Bush NR, Davis RL, Tylavsky, FA. The Impact of the Revised WIC Food Package on Maternal Nutrition during Pregnancy and Postpartum. Am J Epidemiol. 2019; PMID: 31094428.

39. Loftus CT, Hazlehurst MF, Szpiro AA, et al. Prenatal air pollution and childhood IQ: Preliminary evidence of effect modification by folate. Environmental research. 2019;176:108505.

40. Gardner KG, Gebretsadik T, Hartman TJ, Rosa MJ, Tylavsky FA, Adgent MA, Moore PE, Kocak M, Bush NR, Davis RL, Lewinn KZ, Wright RJ, Carroll KN. Prenatal Omega-3 and Omega-6 Polyunsaturated Fatty Acids and Childhood Atopic Dermatitis. J Allergy Clin Immunol Pract. 2019 Oct 15. pii: S2213-2198(19)30857-8. doi: 10.1016/j.jaip.2019.09.031. [Epub ahead of print] PMID: 31626989

41. Tylavsky FA, Ferrara A, Catellier DJ, Oken E, Li X, Law A, Dabelea D, Rundle A, Gilbert-Diamond D, Hivert MF, Breton CV, Cassidy-Bushrow AE, Mueller NT, Hunt KJ, Arteaga SS, Lombo T, Mahabir S, Ruden D, Sauder K, Hedderson MM, Zhu Y, Polk S, Mihalopoulos NL, Vos M, Pyles L, Roary M, Aschner J, Karagas MR, Trasande L. Understanding childhood obesity in the US: the NIH environmental influences on child health outcomes (ECHO) program. Int J Obes (Lond). 2019 Oct 24. doi: 10.1038/s41366-019-0470-5. [Epub ahead of print] PMID: 31649277

42. Anand KJS, Rovnaghi CR, Rigdon J, Qin F, Tembulkar S, Murphy LE, Barr DA, Gotlib IH, Tylavsky FA. Demographic and psychosocial factors associated with hair cortisol concentrations in preschool children. Pediatr Res. 2019 Dec 2. doi: 10.1038/s41390-019-0691-2. [Epub ahead of print] PMID: 31791042

43. Rosa MJ, Hartman TJ, Adgent M, Gardner K, Gebretsadik T, Moore PE, Davis RL, LeWinn KZ, Bush NR, Tylavsky F, Wright RJ, Carroll KN. Prenatal polyunsaturated fatty acids and child asthma: effect modification by maternal asthma and child sex. J Allergy Clin Immunol. 2019 Dec 3. pii: S0091-6749(19)31622-7. doi: 10.1016/j.jaci.2019.10.039. [Epub ahead of print] PMID: 31809758